YMC Gel HG Series

YMC*GEL for preparative HPLC has various available functional groups, such as reversed-phase and normal-phase, and also various particle sizes from 3 µm with high-resolution to 150 µm for open column chromatography. It has achieved considerable improvements in the manufacture of its classical silica base. This has given rise to an improved generation of stationary phases with superior physical attributes.

YMC*GEL is able to work for a long period of time without particle breakage, as it uses high-density and high-strength silica gel. YMC*GEL/YMC*GEL HG packing materials are widely used both domestically and internationally.

Excellent mechanical stability (YMC*GEL HG)

Suitable for separation of peptides

Suited for large-scale purification by using dynamic axial compression column

Packing material for open column chromatography is available

  YMC*Gel
ODS-A-HG
YMC*Gel
ODS-AQ-HG
YMC*Gel
C8-HG (Octyl)
YMC*Gel
C4-HG (Butyl)
Phase Code AAG AQG OCG BUG
Modification C18 C18 C8 C4
Pore Sizes [nm / Å] 12, 20, 30 /
120, 200, 300
8, 12, 20 /
80, 120, 200
12, 20, 30 /
120, 200, 300
12, 20, 30 /
120, 200, 300
Surface Area [m²/g] 330, 175, 100 510, 330, 175, 100 330, 175, 100 330, 175, 100
Particle Sizes [µm] 10, 15, 20, 50
Carbon Load 17, 12, 7% 15, 14, 10% 10, 7, 4% 7, 5, 3%
pH Range 2-7.5
  YMC*Gel
TMS-HG (C1)
Phase Code TMG
Modification Trimethylsilane
Pore Sizes [nm / Å] 12, (20, 30) /
120, (200, 300)
Surface Area [m²/g] 330, (175, 100)
Particle Sizes [µm9 10, 15, 20, 50
Carbon Load 4%
pH Range 2-7.5
  YMC*Gel
CN-HG (Cyano)
YMC*Gel
Ph-HG (Phenyl)
YMC*Gel
NH2-HG (Amino)
Phase Code CNG PHG NHG
Modification Cyanopropyl Phenyl Aminopropyl
Pore Sizes
[nm / Å]
12, (20, 30) /
120, (200, 300)
12, (20, 30) /
120, (200, 300)
12, (20, 30) /
120, (200, 300)
Surface Area [m²/g] 330, (175, 100) 330, (175, 100) 330, (175, 100)
Particle Sizes [µm] 10, 15, 20, 50 10, 15, 20, 50 10, 15, 20, 50
Carbon Load 7% 9% 3%
pH Range 2-7.5 2-7.5 2-7.5
  YMCbasic YMC Omega
Phase Code BA OMG
Modification C8 proprietary
Pore Sizes [nm / Å]
20 / 200 proprietary
Surface Area [m²/g] 175 proprietary
Particle Sizes [µm] 10, 15, 20 10, 20, 50
Carbon Load 7% 15%
pH Range 2-7.5 2-7.5
Phase Code AAG
Modification C18
Pore Sizes 12, 20, 30 nm / 120, 200, 300 Å
Surface Area 330, 175, 100 m2/g
Particle Sizes 10, 15, 20, 50 µm
Carbon Load 17, 12, 7%
pH Range 2-7.5

YMC*Gel ODS-A-HG is YMC’s versatile octadecylsilane (ODS) C18 reversed phase packing material, suitable for a wide variety of applications. Due to its excellent performance and reproducibility it is a fully scalable C18 phase for large-scale preparative purification processes.

Phase Code AQG
Modification C18
Pore Sizes 8; 12, 20, nm / 80; 120, 200, Å
Surface Area 510; 330, 175, 100 m2/g
Particle Sizes 10, 15, 20, 50 µm
Carbon Load 15, 14, 10%
pH Range 2-7.5

YMC*Gel ODS-AQ-HG is a C18 reversed phase silica-based HPLC packing material specifically designed for use in 100% aqueous eluents. As a result of the proprietary derivatisation process, YMC*Gel ODS-AQ-HG exhibits a different selectivity to that of traditional C18 stationary phases. This difference in selectivity of YMC*Gel ODS-AQ-HG can be used to advantage for HPLC separations, which are difficult to achieve with conventional C18 columns, especially for polar compounds.

Phase Code OCG
Modification C8
Pore Sizes 12, 20, 30 nm / 120, 200, 300 Å
Surface Area 330, 175, 100 m2/g
Particle Sizes 10, 15, 20, 50 µm
Carbon Load 10, 7, 4%
pH Range 2-7.5

YMC*Gel C8-HG is one of YMC’s most versatile bonded phases and an excellent alternative to C18 selectivities. Due to its moderate hydrophobicity, YMC*Gel C8-HG is well suited for the separation of hydrophobic compounds which are too strongly retained on C18 phases or for samples that require greater retention than that provided by C4 packings. Compared to C18 phases, retention times of non-polar compounds will be lower on C8 material due to the reduced carbon load.

Phase Code BUG
Modification C4
Pore Sizes 12, 20, 30 nm / 120, 200, 300 Å
Surface Area 330, 175, 100 m2/g
Particle Sizes 10, 15, 20, 50 µm
Carbon Load 7, 5, 3%
pH Range 2-7.5

Due to shorter alkyl chains YMC*Gel C4-HG has a lower hydrophobicity than both C18 and C8 phases. As a result retention times for non-polar samples tend to be shorter on YMC*Gel C4-HG, making it an ideal choice for faster separations.

Phase Code TMG
Modification Trimethylsilane
Pore Sizes 12, (20, 30) nm / 120, (200, 300) Å
Surface Area 330, (175, 100) m2/g
Particle Sizes 10, 15, 20, 50 µm
Carbon Load 4%
pH Range 2-7.5

YMC*Gel TMS-HG shows the lowest retention due to hydrophobic interaction of all reversed phase packing materials. It is useful for fast separations of highly hydrophobic samples that exhibit strong retention characteristics and are difficult or impossible to separate on conventional reversed phase packings. In addition, YMC*Gel TMS-HG can sometimes achieve greater retention and better separations of hydrophilic compounds than other reversed phase columns.

A narrower particle size distribution with lower tendency for the HG-silica material to produce fines translates directly into a reduced backpressure of preparative processes. On average a 7% backpressure reduction can be seen, which increases dramatically with each repacking step.

YMC*Gel is available in a variety of different pore sizes. Pore sizes are usually matched to sample molecule sizes. Pore sizes can also be used to adjust ligand density and hence retention characteristics of a bonded phase, since the size of the pores also affects the total media surface area in a packed column.

The basis for every successful separation is the selection of the appropriate stationary phase. YMC offers one of the world‘s largest portfolios of selectivities, designed to handle even the most demanding separations.

Title Document Type Language Phase Type Download
YMC*Gel HG-series Brochure E Download
YMC*Gel ODS-A-HG Care and Use Care and Use Instructions E Download
MSDS Silica based NP/RP Bulk MSDS E Download
Bulk Packing Material for Preparative Chromatography Overview E Download