YMC HILIC Columns

HILIC HPLC/UHPLC columns from YMC are rugged stationary phases which provide improved LC/ESI-MS response, direct SPE solvent compatibility and complementary selectivity to reversed phases. This is important to R&D and drug metabolism scientists since the impurity or metabolite is frequently more polar and present at much lower concentrations than the parent compound.

With YMC HILIC columns, these very polar compounds elute later than the higher hydrophobic parent compound, thereby minimizing the MS ion suppression that can occur at the beginning of the chromatogram.

YMC HILIC provides an ideal mechanism for the analysis of extremely polar analytes

YMC offers a wide variety of HILIC phases to cover a broad range of polar selectivities

HILIC eluents are compatible with LC-MS systems

  YMC-Triart Diol-HILIC YMC-Pack SIL YMC-Pack PVA-Sil YMC-Pack CN
Modification 1,2-Dihydroxypropyl
(USP L20)
Silica
(USP L3)
Polyvinyl alcohol
(USP L24)
Cyanopropyl
(USP L10)
Particle Size [µm] 1.9, 3, 5 3, 5 5 3, 5
Pore Size
[nm / Å]
12 / 120
6, 12, 20, 30/
60, 120, 200, 300
12 / 120
12, 30 /
120, 300
Surface area [m2/g] 360 450, 330, 175, 100 330 330, 175
pH Range 2.0 - 10.0 2.0 - 7.5 2.0 - 9.5 2.0 - 7.5
  YMC-Pack Diol-NP YMC-Pack Polyamine II YMC-Pack NH2 YMC-Pack TMS
Modification
1,2-Dihydroxypropyl
(USP L20)
Sec./ tert. Amines
(USP L111)
Aminopropylsilane
(USP L8)
Trimethylsilane
(USP L13)
Particle Size [µm] 5 5 3, 5 3, 5
Pore Size
[nm / Å]
6, 12 /
60, 120
12 / 120
12 / 120
12, 30 /
120, 300
Surface area [m2/g] 450, 330 330 330 330, 175
pH Range 2.0 - 7.5 2.0 - 7.5 2.0 - 7.5 2.0 - 7.5
Title Document Type Language Phase Type Download
YMC-Pack Diol NP, PVA-Sil Care and Use Care and Use Instructions E Download
YMC-Pack Polyamine II and NH2 Care and Use Care and Use Instructions E Download
YMC-Pack Silica Care and Use Care and Use Instructions E Download
YMC-Triart Diol-HILIC Care and Use Care and Use Instructions E Download
Analytical stationary phases for HPLC and UHPLC from YMC Overview E Download
YMC Classic Columns eCatalogue E Download
YMC Normal Phase Classics - YMC Classic Columns eCatalogue Chapter E Download