GMP Scale-Up Equipment
The EcoPrime TWIN LPLC is a GMP twin-column system employing ChromaCon’s CaptureSMB process. The pilot and process scale systems thus offer the most productive and least complex multi-column configuration and maximum flexibility. The EcoPrime Twin systems can operate different processes: batch, integrated batch with in-line dilution, CaptureSMB/ AutomAb single column batch, 2-step integrated batch with in-line dilution, alternating batch (flip-flop), CaptureSMB with dynamic control (AutomAB). Customers can also choose different operating software Emerson Delta V or Alan-Bradley / Rockwell Automation.
The EcoPrime TWIN systems are offered as standard systems that can be highly customized, including upstream and downstream sterile connectors for disposables.
Customizable GMP Skid based on standard EcoPrime platform
Pilot to Process scale
Twin-column setup for batch and continuous chromatography
Based on the technology of the Contichrom CUBE
Best available hygienic pump technology from LEWA
Worldwide affiliates and support
| Process capabilities | • TWIN: CaptureSMB only (not batch capable) • TWIN Plus: CaptureSMB plus batch capability (step and linear gradients) • TWIN Plus & BID: CaptureSMB plus batch capability with buffer in-line dilution (BID) • TWIN Plus Consecutive: CaptureSMB plus batch and integrated (consecutive) batch with BID |
| Flow rate range | • EcoPrime TWIN 100: 0.004 – 0.8 L/min • EcoPrime TWIN 300: 0.02 – 3.3 L/min • EcoPrime TWIN 500: 0.06 – 10.0 L/min |
| Pressure rating | 7.5 bar (0.75 MPa, 108 psi) |
| UV detector | 280 nm and 313 nm |
| Conductivity detector | 0 – 200 mS/cm |
| pH range | 0 – 13 |
| Temperature range | Ambient: 4 – 25 °C Process: 4 – 40 °C |
| Dimensions (height x width x depth) | EcoPrimeTwin 100: 145 x 87 x 200 cm (57 x 34 x 79") EcoPrimeTwin 250: 183 x 89 x 200 cm (72 x 35 x 79") EcoPrimeTwin 500: 231 x 112 x 200 cm (91 x 44 x 79") |
| Weight | EcoPrimeTwin 100: 430 kg (950 lb) EcoPrimeTwin 250: 612 kg (1350 lb) EcoPrimeTwin 500: 800 kg (1750 lb) |
| Materials | 316L stainless steel |
| Enclosure protection class | UL Type 4x/IP 65 |