Custom Purification & Analytical Services
YMC will provide complete purification and analytical support for the production of pharmaceutical and functional products with our purification technology which we have developed over many years.
YMC accepts Custom/Contract purification services by using fulfilling facilities, such as preparative devices and columns developed by YMC for purification of Intermediates, APIs, Final products, racemic mixtures-Chiral compounds, Impurities from mg to kg level. We provide satisfactory service with in-house packed materials for purification of products/ optical isomers and column systems that are applicable from lab scale to pilot scale. Please feel free to contact our Lab about the feasibility study or selection of packing materials, column systems, etc. for isolation of your product.
Separation & Purification Services
Our mission is to make chromatography accessible for industrial refinement, academic and purification processes. We are expertise to undertake Chiral & Achiral impurities separation, Process & Method Development for isolation/purification projects. We have high end Instruments and equipment-s which include HPLCs, Flash systems, Prep HPLCs, LCMS, GCMS, HRMS and NMR for structural characterization of compounds with both non GMP, GMP and FDA approved lab facility based on our customer requirements in collaboration with YMC Co. facility.
Our mission is to make chromatography accessible for industrial refinement, academic and purification processes. We are expertise to undertake Chiral & Achiral impurities separation, Process & Method Development for isolation/purification projects. We have high end Instruments and equipment-s which include HPLCs, Flash systems, Prep HPLCs, LCMS, GCMS, HRMS and NMR for structural characterization of compounds with both non GMP, GMP and FDA approved lab facility based on our customer requirements in collaboration with YMC Co. facility.
Chiral Screening, Separation & Purification Support
- Chiral Chromatography Separation
- Chiral screening available with different phases including normal phase, polar organic and reverse phase mode.
- Chiral Method development- providing the best method for your compounds and validation support.
- Chiral purification from mg to multi gm scale in our lab.
- Highly qualified technical team to assist you and provide betier solutions in chiral chromatography.
- Dedicated system for Chiral screening and we make sure our customer requirment is fulfilled.
- Contract purification service: Customer oriented lab facility accommodation by YMC India on Charge/rental basis.
HPLC
- Feasibility studies (agilent 1260, 1290 )
- Qualitative and Quantitative Analysis by HPLC
- Method Development and Method Validation by HPLC
- Chiral method development and separation
- Achiral method development and separation
- Peptide & Impurity analysis
- Impurity identification and quantification
PREP HPLC
YMC's preparative systems are applicable to various preparative scales from small scale to large scale. Our products, such as HPLC systems, hygienic biochromatography and LC Forte/R-II designed for both preparative HPLC and flash purification can respond to customer needs.
K-prep, YMC’s preparative HPLC device, has a wide variety of lineups suitable for a wide range of HPLC purifications from laboratory scale to plant scale. As common software is used in each system, product transfer is seamless. Dynamic axial compression columns, which customers can easily pack, are available as preparative columns. Under usage at constant pressure, these columns maintain their ability.
- Fractioning/Purification in mg to grams
- Enhanced purification efficiency by using ELSD/LCMS
- Low cost purification
- Optical isomers
- Peptides / oligonucleotides
- Pharmaceuticals
- Agricultural chemicals
- Natural products, etc.
Flash Chromatography
- Feasibility studies.
- Method development and Technology Transfer.
- Rapid, time saving, and reproducible high-resolution chromatography.
- Fast and easy purification technique to separate mixtures of molecules into their individual constituents.
- Medium pressure and shorter column chromatography with optimized rapid separation.
- Flash Purification by various phases of Silica (irregular & spherical silica, chemically bonded phases:C18, CN, C4, C8, NH2, SAX, SCX).
- Detectors : DAD & ELSD.
- Flow range: 1-200 mL/min.
- Sample loading: 10 mg to 33 gms.
- Column sizes available: 4 gms to 3 kg.
DAC Systems
- Cost-effective self-packing dynamic axial compression columns
- Superior column performance, endurance and reproducibility provided constant pressure
- Inner diameters from 50 to 1,000 mm
- Compatible with GMP / explosion-proof operation
| System | Column Inner Diameters | Scale | Target Compounds |
| Preparative HPLC device | 50 mmI.D & 100 mmI.D (Packed columns / Axial compression columns) | mg to ton |
|
UHPLC/MS Spectrometry (multimode analysis)
- Method development and method validation
- Shorter run time and enhance sensitivity
- Provides the selectivity, sensitivity, and dynamic range of LC analysis.
- Highly resolved peaks are obtained.
- Agilent 1290 UHPLC with MS single quad Multimode analysis.
- Faster analysis, quantify accurately analytes and related products.
- Low cost analysis due to shorter run time
- Low consumption of solvents.
Chromacon
- Wide range of product purification (chemical & biomolecules)
- High productivity & yield.
- Fast processing of large feed volumes in a short time preserving product integrity.
- Highly resolved peaks are obtained.
- Up to three-fold higher productivity reducing protein A column sizes
- 50% lower buffer consumption compared to a batch process.
Analytical Services
YMC provide wide range of analytical services across pharmaceutical and chemical industries for purifications, testing from raw materials, excipients, APIs, Bulk drugs, intermediates, Natural Products, impurities to finished products.
We also have expertise in isolation and structural elucidation of unknown impurities, Computation evaluation of genotoxic impurities present in your product using required analytical techniques, NMR, HPLC, LCMS etc. Analytical experiments and services are performed by highly qualified & trained chemists, scientists and laboratory management with excellent industry knowledge and vast expertise.
Synthesis Services
YMC offer Custom Synthesis of small molecules, complex organic molecules, Nucleosides, Peptides, protected Amino acids, Oligonucleotides, Pharmaceutical Reference Standards. We undertake route scouting, designing of organic molecules, custom synthesis from small to bulk scale (mg to kg) synthesis of all kinds of API's, Drug intermediates, Impurities, Fine chemicals, Pyridine derivatives, Heterocyclic molecules, specialty chemicals and reference standards compounds. Our synthetic team is expertise and can handle multiple projects with multi step synthesis at once. Our synthetic services includes providing the medicinal chemistry synthesis or custom synthesis, with FFS and FTE model.
- Custom Chemical Synthesis
- Medicinal Chemistry, Library design & synthesis
- Synthesis of Complex & Organic scaffolds, Pharma intermediates
- Synthesis of NCEs
- Impurity & reference standards identification, synthesis & isolation
- Small scale R&D (milli grams) to Process Development (kilograms) & Technology Transfer
- Quick synthesis services with best cost-effective route scouting/design
- Synthesis Success rate of over 95% with 100% assured delivery of committed quantity.
- Every result come with NMR, MS, HPLC data. Additional data will be provided on request.
Nucleoside synthesis
- Wide range of modified & protected nucleosides (DNA/RNA) available.
- Wide range of nucleoside-phosphoramidites are available.
- Wide range of aliphatic phosporamidites are available.
- Synthesis scale – milli grams to kilo grams
Custom DNA/RNA Oligonucleotide Synthesis
- Wide range of Oligo modifications are available.
- We are specialized in modified oligos, fluorescent probes, long oligos and large-scale oligo synthesis.
- Synthesis scale of oligos from 30 μmol to 200 μmol.
- “No Oligo, No Charge” Policy.
Protected Amino Acid Synthesis
Protected Amino groups and protected carboxyl groups of amino acids ( Fmoc, Bn, Bz, Cbz, TBDMs, TBDPS etc)
Impurity Synthesis
YMC offers high quality of Drug Standards , API Impurities, EP,USP,BP impurity standards, Herbal API Impurities, at competitive price globally. we provide and undertake custom synthesis orders for synthesis impurity reference standards in gram levels.
Certificates
