YMC Chiral Bulk
YMC Chiral media is useful for conventional column separations and also for dynamic axial compression (DAC) columns and simulated moving bed (SMB) systems, including a wide range of chiral compounds, cis-trans isomers, and geometric isomers.
They have excellent mechanical strength and chemical stability that can provide excellent peak shape without tailing. Combined with the surprising cost-efficiency, YMC CHIRAL is regarded highly for development or upscaling of chiral purification processes. In addition, method development is simplified by scouting columns for selectivity screening.
Applicable to various chiral compounds
Excellent resolution / durability
High durability applicable to SFC
|CHIRAL ART Amylose-C (Neo)||CHIRAL ART Cellulose-C|
|Phase Code||KAN (KBN)||KCN|
|Particle Sizes [µm]||10, 20|
|pH Range||3.5 - 6.5|
|CHIRAL ART Amylose-SA||CHIRAL ART Cellulose-SB||
|Particle Sizes [µm]||10, 20||10, 20|
|pH Range||2.0 - 9.0||2.0 - 9.0|
For the competitor’s product, loading amount of more than 0.1 mg was not possible because the enantiomeric excess of the 2nd peak was already less than 98%ee with a loading amount of 0.1 mg.
|CHIRAL ART Cellulose-SB||CHIRALPAK® IB|
|1st peak||2nd peak||1st peak||2nd peak|
The calculated maximum loading amount on CHIRAL ART Cellulose-SB of 1.6 mg was 10 times larger than that obtained for the competitor’s product due to the large differences in the peak shapes, even though the interval between repeat injections was higher!
250 x 4.6 mm ID
250 x 20 mm ID
250 x 50 mm ID
|1st peak||2nd peak||1st peak||2nd peak||1st peak||2nd peak|
Linear scale-up was performed using the appropriate scale-up factors. The Dynamic Axial Compression Column self-packed with CHIRAL ART Cellulose-SB 10 μm can be easily and linearly scaled-up for a greater purification scale. The final productivity is 366 and 390 mg/h respectively for peak 1 and 2.
A selection of chiral applications can be foundat http://ymc.de/applications.html. Here, you can search for chiral applications already known for your compounds.
Test Columns or Screening Kits
You can request a test column to initially test a chiral column before finally buy it if it works for your application. If the column is not suitable, simply return it without any further requirements.
Alternatively you can choose one of the YMC method development kits (see page 13) or requesta customised screening kit with 2, 3, 4 or 5 different CHIRAL ART phases. You only need to contact your local YMC contact for details.
FREE Chiral Screening Service
Preparative and Process Scale-Up
|Title||Document Type||Language||Phase Type||Download|
|Robust and Efficient Purification of Enantiomers with CHIRAL ART Cellulose-SB||Application Note||E||Download|
|YMC Chiral Columns||Brochure||E||Download|
|CHIRAL ART Amylose-C, Cellulose-C Prep Care and Use||Care and Use Instructions||E||Download|
|CHIRAL ART Amylose-SA, Cellulose-SB, Cellulose-SC, Cellulose-SJ Prep Care and Use||Care and Use Instructions||E||Download|
|YMC CHIRAL CD, NEA, Prep Care and Use||Care and Use Instructions||E||Download|
|MSDS Silica based NP/RP Bulk||MSDS||E||Download|
|Bulk Packing Material for Preparative Chromatography||Overview||E||Download|