resins YMC Chiral Bulk

YMC Chiral Bulk

YMC Chiral media is useful for conventional column separations and also for dynamic axial compression (DAC) columns and simulated moving bed (SMB) systems, including a wide range of chiral compounds, cis-trans isomers, and geometric isomers.

They have excellent mechanical strength and chemical stability that can provide excellent peak shape without tailing. Combined with the surprising cost-efficiency, YMC CHIRAL is regarded highly for development or upscaling of chiral purification processes. In addition, method development is simplified by scouting columns for selectivity screening.

Applicable to various chiral compounds

Excellent resolution / durability

High durability applicable to SFC

  CHIRAL ART Amylose-C (Neo) CHIRAL ART Cellulose-C
Chiral Selector Amylose Cellulose
 
tris (3,5-dimethylphenyl-
carbamate)
Type coated
Phase Code KAN (KBN) KCN
Particle Sizes [µm] 10, 20
Pore Size widepore
Separation Mode NP/SFC/SMB
pH Range 3.5 - 6.5
  CHIRAL ART Amylose-SA CHIRAL ART Cellulose-SB
CHIRAL ART
Cellulose-SC
Chiral Selector Amylose Cellulose Cellulose
 
tris (3,5-dimethylphenyl-
carbamate)
tris (3,5-dichlorophenyl-
carbamate)
Type immobilised immobilised
Phase Code KSA KSB KSC
Particle Sizes [µm] 10, 20 10, 20
Pore Size widepore widepore
Separation Mode RP/NP/SFC/SMB RP/NP/SFC/SMB
pH Range 2.0 - 9.0 2.0 - 9.0

For the competitor’s product, loading amount of more than 0.1 mg was not possible because the enantiomeric excess of the 2nd peak was already less than 98%ee with a loading amount of 0.1 mg.

  CHIRAL ART Cellulose-SB CHIRALPAK® IB
  1st peak 2nd peak 1st peak 2nd peak
Enantiomeric excess >99.9%ee 99.3%ee >99.9%ee 97.9%ee
Recovery 99% 99% 99% 97%
Productivity (mg/h) 3.1 3.3 0.3 0.3

The calculated maximum loading amount on CHIRAL ART Cellulose-SB of 1.6 mg was 10 times larger than that obtained for the competitor’s product due to the large differences in the peak shapes, even though the interval between repeat injections was higher!

  Analytical
250 x 4.6 mm ID
YMC-Actus
Semi-preparative
250 x 20 mm ID		 Self-packed
DAC Preparative
250 x 50 mm ID
  1st peak 2nd peak 1st peak 2nd peak 1st peak 2nd peak
Enantiomeric excess >99.9%ee >99.3%ee >99.9%ee >99.8%ee >99.1%ee >99.3%ee
Recovery 99% 99% 97% 99% 99% 94%
Productivity (mg/h) 3.1 3.3 58.6 62.4 366 390

Linear scale-up was performed using the appropriate scale-up factors. The Dynamic Axial Compression Column self-packed with CHIRAL ART Cellulose-SB 10 μm can be easily and linearly scaled-up for a greater purification scale. The final productivity is 366 and 390 mg/h respectively for peak 1 and 2.

YMC Database
A selection of chiral applications can be foundat http://ymc.de/applications.html. Here, you can search for chiral applications already known for your compounds.

Test Columns or Screening Kits
You can request a test column to initially test a chiral column before finally buy it if it works for your application. If the column is not suitable, simply return it without any further requirements.
Alternatively you can choose one of the YMC method development kits (see page 13) or requesta customised screening kit with 2, 3, 4 or 5 different CHIRAL ART phases. You only need to contact your local YMC contact for details.

FREE Chiral Screening Service

  • >90% success rate
  • Rapid screening within a short period of time
  • Screening according to your requirements: e.g. RP-mode, MS-compatibility etc.
  • Screening on all available CHIRAL ART phases and further YMC CHIRAL phases if needed
  • Results presented in a detailed report
  • Confidentiality Agreements can be arranged as necessary

    • Success Rate

  • Hit criteria : Rs>1.5
  • Hit database: compiled from 300 samples (199 LC/101 SFC) supplied for contract service
  • The 5 CHIRAL ART phases available so far can cover >90% of chiral separations
  • Hit ratios varied between 6% and 34% for each of the 5 phases
  • About 95% of the LC applications are in NP/PO mode, while 5% are in RP mode

    • Method Development

  • Method development based on phase screening
  • According to your requirements

    • Preparative and Process Scale-Up

  • Phase screening
  • Preparative method development
  • Small scale purification

    • Title Document Type Language Phase Type Download
    Robust and Efficient Purification of Enantiomers with CHIRAL ART Cellulose-SB Application Note E Download
    YMC Chiral Columns Brochure E Download
    CHIRAL ART Amylose-C, Cellulose-C Prep Care and Use Care and Use Instructions E Download
    CHIRAL ART Amylose-SA, Cellulose-SB, Cellulose-SC, Cellulose-SJ Prep Care and Use Care and Use Instructions E Download
    YMC CHIRAL CD, NEA, Prep Care and Use Care and Use Instructions E Download
    MSDS Silica based NP/RP Bulk MSDS E Download
    Bulk Packing Material for Preparative Chromatography Overview E Download